Dihydropyridine derivatives, their preparation and their use

Details Dihydropyridine derivatives, their preparation and their use Dihydropyridine derivatives, their preparation and their use

C - Chemistry, Metallurgy

07

D

260/278, 260/279

C07D 401/12 (2006.01) C07D 211/90 (2006.01)

Patent

CA 1309098

ABSTRACT 2-(Amino or methyl)-6-(methyl or amino)-4- (substituted phenyl)-1,4-dihydropyridine-3,5- dicarboxylic acid esters have a specific class of heterocyclic groups as the alcohol moiety. These compounds have a variety of valuable activities, including antihypertensive and Ca++-blocking activities, leading to their use for the treatment of circulatory and coronary disorders. They may be prepared by condensation of appropriate substituted benzylideneacetoacetic acid esters with appropriate amidinoacetic acid esters.

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