Dihydropyridine derivatives useful in antitumor therapy

Details Dihydropyridine derivatives useful in antitumor therapy Dihydropyridine derivatives useful in antitumor therapy

C - Chemistry, Metallurgy

07

D

C07D 413/14 (2006.01) A61K 31/44 (2006.01) A61K 31/535 (2006.01) C07D 213/80 (2006.01) C07D 401/10 (2006.01) C07D 401/14 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2078606

DIHDROPYRIDINE DERIVATIVES USEFUL IN ANTITUMOR THERAPY Image (I) (.alpha.) (.beta.) Image Image (?) Image (?) (i) -(CH2m-CH=CH-Ph, (ii) Image , (iii) Image , (iv) Image ; Abstract Dihydropyridine derivatives or formula (I), wherein Het is .alpha. or .beta. ; A reprssents a direct linkage, -CH2-,-CH2-CH2-or, when Het is .alpha. may also represent -CH=CH-; R is hydrogen or halogen; C1-C3 alkyl or C1-C3 alkoxy; one of R3 and R4 is C1-C3 alkyl optionally omega substituted by C1-C3 alkoxy and the other is independently C1-C3 alkyl optionally substituted by C1-C3 al- koxy or (?); R5 is hydrogen or C1-C6 alkyl optionally substi- Abstract - 2 - tuted by -N(RcRd); one of R1 and R2 is a group -OR' wherein R' is C1-C6 alkyl optionally substituted by C1-C3 alkoxy or cyano, and the other is independently a) Cl-C3 alkyl, b) a group -OR', c) a group (?) or d) a group -ORIV wherein RIV is hydrogen or a substituent selected from (i), (ii), (iii) and (iv), are useful antitumor activity promoting agents.

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