Dihydropyridine npy antagonists: piperidine derivatives

Details Dihydropyridine npy antagonists: piperidine derivatives Dihydropyridine npy antagonists: piperidine derivatives

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/44 (2006.01) C07D 211/90 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2177110

A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of piperidine and tetrahydropyridine derivatives of 4-phenyl-1,4-dihydropyridines of Formula I. Image (I) As antagonists of NPY-induced feeding behavior, these compounds are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.

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