Dihydropyridine spray, process for its preparation and its...

Details Dihydropyridine spray, process for its preparation and its... Dihydropyridine spray, process for its preparation and its...

A - Human Necessities

61

K

167/229

A61K 31/44 (2006.01) C07D 213/80 (2006.01) C09K 3/30 (2006.01)

Patent

CA 1281654

23189-6430 Dihydropyridine Spray, Process for its Preparation and its Pharmaceutical Use ABSTRACT OF THE DISCLOSURE A sprayable liquid formulation comprising, per 100 ml of the formulation, a) 0.2 to 5 grams of a dihydropyridine of the formula Image in which R1 and R2 each independently is alkyl with 1 to 10 carbon atoms optionally substituted by alkoxy with 1 to 3 carbon atoms, trifluoromethyl, halogen or N-methyl- N- benzylamino, R3 is alkyl with 1 to 4 carbon atoms, cyano or hydroxymethyl, and X is a nitro group, one or two chlorine groups or the ring member =N-O-N=, b) 10 to 40 grams of polyethylene glycol with an average molecular weight of 200 to 600, c) 25 to 60 grams of ethyl alcohol, and d) 3 to 15 grams of polyvinylpyrrolidine with an average molecular weight of 12000 to 30000.

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