C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/276.2
C07D 491/048 (2006.01) A61K 31/44 (2006.01) C07D 491/04 (2006.01)
Patent
CA 1293508
Abstract Reducing blood sugar with the novel dihydropyridine- lactols, or salts thereof, of the formula Image in which R1 represents a phenyl, naphthyl, thienyl, pyridyl, chromonyl, thiochromonyl or thiochromenyl radi- cal, the stated radicals optionally containing 1 or 2 identical or different substituents from the group consisting of fluorine, chlorine and bromine, alkyl, alkoxy and alkylthio, each having 1 to 6 carbon atoms, and fluoroalkyl or fluoroalkoxy, each having up to 3 carbon atoms and 3 fluorine atoms, and nitro and cyano, R2 represents a straight-chain, branched or cyclic alkyl having up to 12 carbon atoms which is op- tionally inte rupted by 1 or 2 oxygen or sulphur atoms and which is optionally substituted by fluo- rine, chlorine, phenyl, cyano, hydroxyl, amino, C1-C3-alkylamino, di-C1-C3-alkylamino or N-benzylmethylamino, R3 represents cyano or straight-chain or branched alkyl which has up to 4 carbon atoms and is optionally interrupted in the chain by N-C1-C3-alkyl and/or oxygen, and R4 represents straight-chain, branched or cyclic alkyl which has up to 6 carbon atoms and is optionally interrupted by 1 or 2 oxygen atoms and is substituted by one or more radicals from amongst fluorine, chlorine, hydroxyl, phenyl, amino, carboxyl and C1-C4-alkoxycarbonyl.
517282
Ahr Hans Jurgen
Bender Joachim
Bischoff Hilmar
Bossert Friedrich
Goldmann Siegfried
Aktiengesellschaft Bayer
Fetherstonhaugh & Co.
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