Dihydropyridines

Details Dihydropyridines Dihydropyridines

C - Chemistry, Metallurgy

07

D

260/294.2, 260/2

C07D 211/90 (2006.01) C07D 401/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 1205471

Abstract New compounds useful as therapeutical agent and useful as intermediates for the preparation of other therapeuti- cally active dihydropyridines, which new compounds are of the formula Image I wherein R1 is one or two (the same or different) substituents on the phenyl ring selected from the group consisting of lower alkyl, NO2, CN, CF3, Cl and Br; A is a straight or branched alkylene group with 2-5 carbon atoms; R2 is Image wherein B is a straight or branched alkylene group with 2-5 carbon atoms and R3 and R6 are the same or different and each represents a straight or branched alkyl group with 1-5 carbon atoms, an alkylaryl group or both together are part of a 5-7 membered heterocyclic ring; R4 is a straight or branched alkyl group with 1-5 carbon atoms in which alkyl group the carbon chain is interrupted by an oxygen atom; R5 is a lower alkyl group, or a physio- logically acceptable salt or optical isomer thereof, process- es for the preparation of said compounds; pharmaceutical preparations containing said compounds, a method for their therapeutical use and a new process using said compounds as intermediates.

427276

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