Dihydropyridone amides as p2x7 modulators

Details Dihydropyridone amides as p2x7 modulators Dihydropyridone amides as p2x7 modulators

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61K 31/455 (2006.01) A61K 31/497 (2006.01) A61K 31/501 (2006.01) A61K 31/506 (2006.01) A61K 31/53 (2006.01) A61P 3/10 (2006.01) A61P 11/06 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) C07D 211/90 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2745952

Compounds of the formula (I) or pharmaceutically acceptable salts thereof, wherein m, n, p, q, R1, R2, R3, R4, R5 and R6 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.

L'invention concerne des composés représentés par la formule (I) ou des sels pharmaceutiquement acceptables de ceux-ci, m, n, R1, R2, R3, R4, R5 et R6 étant tels que définis dans la demande. L'invention concerne aussi des procédés de fabrication de ces composés et d'utilisation de ceux-ci pour traiter des maladies associées au récepteur purinergique P2X7.

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