C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/14 (2006.01) A61K 31/495 (2006.01) A61K 31/50 (2006.01) A61P 3/10 (2006.01) A61P 9/02 (2006.01) A61P 29/00 (2006.01) C07D 487/12 (2006.01)
Patent
CA 2732797
A compound having the structure set forth in Formula (I) and Formula (II) wherein the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.
L'invention concerne un composé ayant la structure présentée dans la formule (I) et la formule (II) dans lesquelles les substituants Y, Z, A, B, R1, R2, R3, R4 et R5 sont définis ici. L'invention concerne des inhibiteurs d'activité poly(ADP-ribose)polymérase. Elle concerne aussi des compositions pharmaceutiques qui comprennent au moins un composé décrit ici et l'utilisation d'un composé ou d'une composition pharmaceutique décrit ici pour traiter des maladies, des affections et des états qui sont améliorés par l'inhibition de l'activité PARP.
Chu Daniel
Wang Bing
Biomarin Pharmaceutical Inc.
Osler Hoskin & Harcourt Llp
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