Dihydropyrimidines and uses thereof

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 239/22 (2006.01) C07D 401/14 (2006.01) C07D 491/04 (2006.01) C07D 491/048 (2006.01)

Patent

CA 2355848

This invention is directed to dihydropyrimidines which are selective antagonists for human .alpha.1a receptors. This invention is also related to uses of these compounds for relaxing lower urinary tract tissue, treating benign prostatic hyperplasia and for the treatment of any disease where the antagonism of the .alpha.1a receptor may be useful. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.

La présente invention concerne des dihydropyrimidines constituant des antagonistes sélectifs des récepteurs humains .alpha.¿1a?. L'invention concerne également des utilisations de ces composés visant à détendre les tissus des voies urinaires inférieures, à traiter l'hyperplasie prostatique bénigne et toute maladie dans laquelle l'antagonisme du récepteur .alpha.¿1a? peut être utile. L'invention concerne enfin une composition pharmaceutique renfermant une quantité thérapeutiquement efficace des composés définis ci-dessus ainsi qu'un excipient acceptable d'un point de vue pharmaceutique.

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