Dihydropyrimidines and uses thereof

Details Dihydropyrimidines and uses thereof Dihydropyrimidines and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 239/22 (2006.01) A61K 31/505 (2006.01) A61K 31/675 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 487/04 (2006.01) C07D 491/04 (2006.01) C07D 491/048 (2006.01) C07D 495/04 (2006.01) C07F 9/6512 (2006.01) C07F 9/6561 (2006.01)

Patent

CA 2237774

This invention is directed to dihydropyrimidine compounds which are selective antagonists for human .alpha.1A receptors. This invention is also related to uses of these compounds for lowering intraocular pressure, inhibiting cholesterol synthesis, relaxing lower urinary tract tissue, the treatment of begnin prostatic hyperplasia, impotency, cardiac arrythmia and for the treatment of any disease where the antagonism of the .alpha.1A receptor may be useful. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.

Cette invention concerne des composés de dihydropirimidines constituants des antagonistes sélectifs des récepteurs .alpha.¿1A? humains. Cette invention concerne également des utilisations de ces composés pour abaisser la pression intra-occulaire, inhiber la synthèse du cholestérol, décontracter les tissus des voies urinaires inférieures, le traitement de l'adénome prostatique, de l'impuissance, de l'arythmie cardiaque et dans le traitement de toutes maladies dans lesquelles l'antagonisme du récepteur .alpha.¿1A? peut être utile. L'invention concerne en outre une composition pharmaceutique comprenant une dose thérapeutique efficace des composés ci-dessus définis ainsi qu'un excipient pharmaceutiquement acceptable.

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