Dihydropyrimidines and uses thereof

Details Dihydropyrimidines and uses thereof Dihydropyrimidines and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61K 31/535 (2006.01) C07D 239/22 (2006.01) C07D 401/06 (2006.01) C07D 401/10 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 451/06 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 491/04 (2006.01) C07D 491/044 (2006.01) C07D 495/04 (2006.01) C07D 519/00 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2253862

This invention is directed to dihydropyrimidine compounds which are selective antagonists for human .alpha.1A receptors. This invention is also related to uses of these compounds for lowering intraocular pressure, inhibiting cholesterol synthesis, relaxing lower urinary tract tissue, the treatment of benign prostatic hyperplasia, impotency, cardiac arrhythmia and for the treatment of any disease where the antagonism of the .alpha.1A receptor may be useful. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.

L'invention concerne des composés de dihydropyrimidine qui sont des antagonistes sélectifs de récepteurs humains .alpha.¿1A?. L'invention concerne également les emplois desdits composés pour abaisser la pression intraoculaire, inhiber la synthèse du cholestérol, soulager le tissu du bas appareil urinaire, ainsi que pour traiter l'hyperplasie prostatique bénigne, l'impuissance, l'arythmie cardiaque et toute autre maladie pour laquelle l'antagonisme du récepteur .alpha.¿1A? peut être utile. L'invention décrit en outre une composition pharmaceutique contenant une dose thérapeutiquement efficace des composés susmentionnés et un excipient pharmaceutiquement admissible.

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