Dihydropyrimidines and uses thereof

Details Dihydropyrimidines and uses thereof Dihydropyrimidines and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 239/22 (2006.01) A61K 31/505 (2006.01) C07D 239/30 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 451/06 (2006.01) C07D 471/08 (2006.01) C07D 491/02 (2006.01) C07D 491/04 (2006.01) C07D 495/04 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2205384

-234- DIHYDROPYRIMIDINES AND USES THEREOF Abstract of the Disclosure This invention is directed to dihydropyrimidine compounds of the following formula: Image which are selective antagonists for human ale receptors. This invention is also related to uses of these compounds for lowering intraocular pressure, inhibiting cholesterol synthesis, relaxing lower urinary tract tissue, the treatment of benign prostatic hyperplasia, impotence, cardiac arrhythmia and for the treatment of any disease where antagonism of the ale receptor may be useful. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.

Cette invention se rapporte à des composés dihydropyrimidine qui sont des antagonistes sélectifs pour les récepteurs alpha 1C humains, ainsi qu'aux utilisations de ces composés dans la réduction de la pression intraoculaire, l'inhibition de la synthèse du cholestérol, le relâchement des tissus inférieurs des voies urinaires, le traitement de l'hyperplasie prostatique bénigne, l'impuissance, l'arythmie cardiaque et le traitement de toutes maladies pour lesquelles l'antagonisme du récepteur alpha 1C peut être utile. L'invention se rapporte encore à une composition pharmaceutique comprenant une quantité thérapeutiquement efficace des composés définis ci-dessus et à un excipient pharmaceutiquement acceptable.

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