Dihydropyrimidinones for use as bace2 inhibitors

Details Dihydropyrimidinones for use as bace2 inhibitors Dihydropyrimidinones for use as bace2 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 239/22 (2006.01) A61K 31/513 (2006.01) A61K 31/527 (2006.01) A61P 3/10 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2760343

This invention relates to dihydropyrimidinones of the formula (I), wherein X and R1 to R7 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are BACE2 inhibitors and can be used as medicaments for the treatment or prevention of diseases such as diabetes.

La présente invention concerne des dihydropyrimidinones de formule (I), dans laquelle X et R1à R7 sont tels que définis dans la description et les revendications, ainsi que les sels pharmaceutiquement acceptables de ceux-ci. Ces composés sont des inhibiteurs de BACE2 et peuvent être utilisés comme médicaments dans le traitement ou la prévention de maladies telles que le diabète.

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