Dihydropyrimidopyrimidine derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61K 45/00 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2745959

The invention relates to compounds represented by the general formula (I) and the like. In the formula, Ar1 denotes an aryl or heteroaryl group which may have a substituent; R1 denotes a hydrogen atom, or denotes a C1-C6 alkyl, aryl, aralkyl or heteroaryl group which may have a substituent; R2 denotes an aralkyl group or a group represented by the formula (a); and R3 denotes a hydrogen atom or a C1-C6 alkyl group. The compounds of the invention have an excellent Weel kinase inhibitory effect, and therefore are useful in the field of medicine, especially in the field of treatment of various cancers.

Cette invention concerne, parmi d'autres, un composé représenté par la formule générale (I) ci-dessous. Dans cette formule, Ar1 désigne un groupe aryle ou hétéroaryle pouvant avoir un substituant ; R1 est un atome d'hydrogène ou un groupe alkyle en C1-C6, aryle, aralkyle ou hétéroaryle pouvant avoir un substituant ; R2 est un groupe aryle ou un groupe aralkyle représenté par la formule (a); et R3 désigne un atome d'hydrogène ou un groupe alkyle en C1-C6. Les composés de la présente invention possèdent un excellent effet inhibiteur de la kinase Weel et sont par la même particulièrement utiles en médecine, en particulier dans divers types de thérapie du cancer.

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