Dihydropyrimidothiazine derivatives

Details Dihydropyrimidothiazine derivatives Dihydropyrimidothiazine derivatives

C - Chemistry, Metallurgy

07

D

167/212, 260/255

C07D 513/04 (2006.01) A61K 31/505 (2006.01) C07D 239/22 (2006.01)

Patent

CA 2021556

DIHYDROPYRIMIDOTHIAZINE DERIVATIVES A b s t r a c t The invention relates to new dihydropyrimido- thiazine derivatives, a process for the preparation there- of, pharmaceutical compositions comprising the same and new intermediates useful in the preparation of the said dihydropyrimidothiazine derivatives. The new dihydropyrimidothiazine derivatives of the general formula I, Image I wherein R1 represents C1-6 alkoxy, amino or phenylamino, R2 stands for C1-6 alkyl or phenyl, R3 represents hydrogen or C1-6 alkyl, and R4 denotes C1-11 alkyl or phenyl optionally bearing one or more identical or different substituent/s/ selected from halogen, nitro, Amino, di-(C1-6 alkyl)-amino, C1-6 alkyl, C1-6 alkoxy and hydroxy, and pharmaceutically acceptable acid addition salts there- of exert valuable antianginal and/or antiinflammatory effect/s/ and are useful is therapy.

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