Dihydropyrones with improved antiviral activity

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 309/32 (2006.01) A61K 31/365 (2006.01) A61K 31/38 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07C 49/245 (2006.01) C07C 49/255 (2006.01) C07C 59/48 (2006.01) C07C 59/52 (2006.01) C07C 59/68 (2006.01) C07C 69/732 (2006.01) C07C 69/738 (2006.01) C07C 205/45 (2006.01) C07C 225/22 (2006.01) C07C 233/33 (2006.01) C07C 271/06 (2006.01) C07C 381/04 (2006.01) C07D 233/84 (2006.01) C07D 295/205 (2006.01) C07D 295/26 (2006.01) C07D 405/04 (2006.01) C07D 405/1

Patent

CA 2263429

This invention pertains to improved antiviral activity of 6,6-disubstituted- 5,6-dihydropyran-2-ones caused by judicious placement of certain polar substituents at the 3 and/or 6 positions. The same substituents which enhance the cellular activity also diminish cytotoxicity further enhancing the desirable properties of these agents as antivirals.

La présente invention concerne une amélioration de l'activité antivirale de 5,6-dihydropyran-2-ones disubstitués en 6,6 obtenue grâce à une disposition judicieuse de substituants en positions 3 et/ou 6. Ces mêmes substituants qui renforcent l'activité cellulaire diminuent également la cytotoxicité, ce qui renforce encore plus les propriétés souhaitables de ces agents comme antiviraux.

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