C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/454 (2006.01) A61K 31/497 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2534065
The present invention relates to dihydropyrrole compounds of Formula (I) that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention is also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
La présente invention a trait à des composés de dihydropyrrole de formule (I) utiles pour le traitement de maladies de prolifération cellulaire, pour le traitement de troubles associés à une activité de la kinésine KSP, et pour l'inhibition de la kinésine KSP. L'invention a également trait à des compositions comportant ces composés, et à leurs procédés d'utilisation pour le traitement du cancer chez des mammifères.
Coleman Paul J.
Cox Christopher D.
Garbaccio Robert M.
Hartman George D.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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