C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 455/06 (2006.01) A61K 31/473 (2006.01) A61P 25/14 (2006.01)
Patent
CA 2555815
The invention provides novel isomers of dihydrotetrabenazine, individual enantiomers and mixtures thereof wherein the dihydrotetrabenazine is a 3,11 b- cis- dihydrotetrabenazine. Also provided are methods for the preparation of the novel isomers, pharmaceutical compositions containing them and their use in treating hyperkinetic movement disorders such as Huntington's disease, hemiballismus, senile chorea, tic, tardive dyskinesia and Tourette's syndrome.
L'invention concerne de nouveaux isomères de dihydrotétrabénazine, des énantiomères individuels et des mélanges de ceux-ci, la dihydrotétrabénazine étant une 3,11 b-cis-dihydrotétrabénazine. L'invention concerne également des méthodes de préparation de ces nouveaux isomères, des compositions pharmaceutiques les contenant, et leur utilisation dans le traitement des troubles du mouvement hypercinétiques tels que la maladie d'Huntington, l'hémiballisme, la chorée sénile, les tics, la dyskinésie tardive et le syndrome de Tourette.
Clarke Ian
Johnston Grant
Tridgett Robert
Turtle Robert
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Biovail Laboratories International (barbados) Srl
Cambridge Laboratories (ireland) Limited
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