Dihydroxy open-acid and salts of hmg-co-a reductase inhibitors

Details Dihydroxy open-acid and salts of hmg-co-a reductase inhibitors Dihydroxy open-acid and salts of hmg-co-a reductase inhibitors

A - Human Necessities

61

K

A61K 31/22 (2006.01) A61K 9/28 (2006.01) A61P 3/06 (2006.01)

Patent

CA 2364253

The instant invention provides methods and pharmaceutical compositions for inhibiting HMG-CoA reductase, as well as for treating and/or reducing the risk for diseases and conditions affected by inhibition of HMG-CoA reductase, comprising orally administering a therapeutically effective amount of a compound selected from a dihydroxy open acid statin and a pharmaceutically acceptable salt or ester thereof in a delayed-release pharmaceutical dosage form to a patient in need of such treatment wherein substantial release of the compound from the dosage form is delayed until after passage of the dosage form through the stomach.

L'invention concerne des procédés et des compositions pharmaceutiques pour l'inhibition de la HMG-CoA réductase, ainsi que pour le traitement et/ou la réduction du risque de maladies et d'états modifiés par l'inhibition de la HMG-CoA réductase. Lesdits procédés consistent à administrer par voie orale une dose efficace au plan thérapeutique d'un composé choisi parmi une statine d'acide ouvert en dihydroxy, un sel acceptable au plan pharmaceutique ou un ester, dans une forme galénique à effet retard, à un patient ayant besoin dudit traitement, la libération du composé par la forme galénique étant retardée jusqu'à ce que la forme galénique soit passée dans l'estomac.

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