C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 69/30 (2006.01) A61K 9/28 (2006.01) A61K 9/52 (2006.01) A61K 31/22 (2006.01) A61P 3/06 (2006.01) A61P 9/10 (2006.01) A61P 43/00 (2006.01) C07C 67/28 (2006.01) C07C 67/52 (2006.01) C07C 67/56 (2006.01)
Patent
CA 2421018
The instant invention provides methods and pharmaceutical compositions for inhibiting HMG-CoA reductase, as well as for treating and/or reducing the risk for diseases and conditions affected by inhibition of HMG-CoA reductase, comprising orally administering a therapeutically effective amount of a crystalline hydrated form of the calcium salt of dihydroxy open acid simvastatin to a patient in need of such treatment. Methods for making the calcium salt of dihydroxy open acid simvastatin are also provided.
L'invention concerne des méthodes et des compositions pharmaceutiques permettant d'inhiber la HMG-CoA réductase et de traiter des maladies et/ou de réduire le risque de maladies et de conditions affectées par l'inhibition de la HMG-CoA réductase. Les méthodes consistent à administrer oralement à un patient une quantité thérapeutiquement efficace d'une forme cristalline hydratée du sel de calcium de simvastatine d'acide ouvert dihydroxy. L'invention concerne également un procédé de fabrication du sel de calcium de simvastatine d'acide ouvert dihydroxy.
Grabaowski Edward J. J.
Reider Paul J.
Tillyer Richard D.
Varsolona Richard J.
Vega Jose M.
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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