Dihydroxyphenylalanine derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 339/04 (2006.01) A61K 31/16 (2006.01) A61K 31/166 (2006.01) A61K 31/385 (2006.01) A61P 25/16 (2006.01) C07C 233/49 (2006.01) C07C 233/87 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2607198

The invention relates to dihydroxyphenylalanine derivatives, the production thereof, and pharmaceutical compositions containing said dihydroxyphenylalanine derivatives. The invention further relates to the use of said dihydroxyphenylalanine derivatives and pharmaceutical compositions for the treatment and prevention of movement disorders, neurodegenerative diseases, Alzheimer, Parkinson's disease, hemiatrophy hemiparkinsonism, Parkinson's syndrome, Lewy bodies disease, frontotemporal dementia, Lytico- Bodig disease (Parkinsonism-dementia-amyotrophic lateral sclerosis, striatonigral degeneration, Shy-Drager syndrome, sporadic olivopontocerebellar degeneration, progressive pallidal atrophy, progressive supranuclear palsy, Hallervorden-Spatz disease, Huntington's disease, X chromosome-linked dystonia (Morbus Lubag), mitochondrial cytopathy with striatal necrosis, neuroacanthocytosis, restless leg syndrome, Wilson's disease.

L'invention concerne des dérivés de dihydroxyphénylalanine dont la production et les compositions pharmaceutiques contiennent ces dérivés de dihydroxyphénylalanine. L'invention concerne également l'utilisation de ces dérivés de dihydroxyphenylalanine et les compositions pharmaceutiques destinées au traitement et à la prévention de troubles locomoteurs, de maladies neurodégénératives, de la maladie d'Alzheimer, de Parkinson, d'hémiatrophie-hémiparkinson, du syndrome de Parkinson, de la maladie des corps de Lewy, la démence fronto-temporale, la maladie Lytico-Bodig (Parkinsonisme-démence-sclérose latérale amyotrophique), la dégénération striatonigrale, le syndrome Shy-Drager, la dégénération sporadique olivo-ponto-cerébelleuse, l'atrophie pallidale progressive, la paralysie supranucléaire progressive (progressive supranuclear palsy), maladie de Hallervorden-Spatz, maladie de Huntington, dystonie liée au chromosome x (Morbus Lubag), cytopathie mitochondriale avec nécrose striatale, neuroakanthocytose, syndrome des jambes sans repos, maladie de Wilson.

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