C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/557 (2006.01) A61K 31/505 (2006.01) A61P 31/12 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/04 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/04 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2418288
A class of 2-aryl-4, 5-dihydroxy-6-carboxypyrimidines of formula (I): wherein Ar is an optionally substituted aryl or heterocyclicgroup; as well as compounds of formula (I) which are derivatised at one or more of the 4- hydroxy, 5-hydroxy or 6-carboxy groups; and tautomers thereof, and pharmaceutically acceptable salts or esters thereof; and inhibitors of viral polymerases, especially thehepatitis C virus (HCV) polymerase enzyme.
L'invention concerne une catégorie de 2-aryl-4, 5-dihydroxy-6-carboxypyrimidines représentées par la formule (I) : dans laquelle Ar représente un groupe aryle ou hétérocyclique éventuellement substitué. L'invention concerne également des composés représentés par la formule (I), qui sont dérivés au niveau de l'un ou de plusieurs des groupes 4-hydroxy, 5-hydroxy ou 6-carboxy ; leurs tautomères, leurs sels ou esters pharmaceutiquement acceptables ; et des inhibiteurs de polymérases virales, notamment la polymérase du virus de l'hépatite C (VHC).
Gardelli Cristina
Giuliano Claudio
Harper Steven
Koch Uwe
Narjes Frank
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.p.a.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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