Diketohydrazine derivative compounds and drugs containing...

C - Chemistry – Metallurgy – 07 – C

Patent

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C07C 243/24 (2006.01) A61K 31/16 (2006.01) A61K 31/165 (2006.01) A61K 31/341 (2006.01) A61K 31/351 (2006.01) A61K 31/40 (2006.01) A61K 31/4025 (2006.01) A61K 31/4035 (2006.01) A61K 31/4152 (2006.01) A61K 31/4166 (2006.01) A61K 31/4168 (2006.01) A61K 31/421 (2006.01) A61K 31/423 (2006.01) A61K 31/425 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61K 31/428 (2006.01) A61K 31/429 (2006.01) C07C 243/34 (2006.01) C07C 251/76 (2006.01) C07C 251/84 (2006.01) C07C 251/86 (2006.01) C07D 207/22 (2006.01) C07

Patent

CA 2483998

Diketohydrazine derivatives represented by the following general formula (I) (wherein each symbol is as defined in the description) and pharmaceutically acceptable salts thereof: (I) Because of having a cysteine protease inhibitory activity, the compounds represented by the general formula (I) are useful as remedies for inflammatory diseases, immune diseases, ischemic diseases, respiratory diseases, circulatory diseases, blood diseases, nerve diseases, liver/biliary duct diseases, bone/joint diseases, metabolic diseases and so on. Because of having an elastase inhibitory activity, these compounds are also useful as remedies for COPD (chronic obstructive pulmonary disease) and so on.

L'invention concerne des dérivés de dicétohydrazine représentés par la formule générale (I), dans laquelle chaque symbole est tel que défini dans la description, ainsi que des sels pharmaceutiquement acceptables desdits composés. Du fait de leur activité inhibitrice de la cystéine protéase, les composés représentés par la formule générale (I) sont utiles comme agents thérapeutiques destinés à traiter les maladies inflammatoires, les maladies immunitaires, les maladies ischémiques, les maladies respiratoires, les maladies circulatoires, les maladies du sang, les maladies du système nerveux, les maladies du foie/voie biliaire, les maladies osseuses/articulaires, les maladies métaboliques, etc. Du fait de leur activité inhibitrice de l'élastase, lesdits composés sont également utiles comme agents thérapeutiques destinés à traiter la BPCO (bronchopneumopathie chronique obstructive), etc.

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