A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/55 (2006.01) A61K 9/50 (2006.01) A61K 9/58 (2006.01)
Patent
CA 2068980
ABSTRACT OF THE DISCLOSURE The present invention is directed to a diltiazem for- mulation suitable for one a day administration. The for- mulation contains a blend of diltiazem beads having two differing dissolution profiles. One type of bead is a rapid release bead which releases up to 100% of the dil- tiazem it contains within approximately 6 to 8 hours of administration. The second bead is a delayed release diltiazem bead and substantial quantities of diltiazem are not released from this bead until approximately 12 hours after administration with the majority of the dil- tiazem being released at 16 to 24 hours after administra- tion. The diltiazem formulation will typically contain from 25% to 60% w/w of the rapid release beads and from 40% to 75% w/w of the delayed release beads. Both the rapid release and the delayed release beads are made up of two parts, one being a central core containing the diltiazem while the other is a polymeric coating which envelops the central core.
Baltezor Michael J.
Dimmitt Dan C.
Hendrickson Dennis L.
Skultety Paul F.
Williams Mark S.
Marion Merrell Dow Inc.
Osler Hoskin & Harcourt Llp
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