Dimer-selective rxr modulators and methods for their use

Details Dimer-selective rxr modulators and methods for their use Dimer-selective rxr modulators and methods for their use

C - Chemistry, Metallurgy

07

C

C07C 59/72 (2006.01) A61K 31/13 (2006.01) A61K 31/192 (2006.01) A61K 31/21 (2006.01) A61K 31/33 (2006.01) A61K 31/425 (2006.01) A61K 31/44 (2006.01) A61K 31/4418 (2006.01) A61K 38/28 (2006.01) A61K 45/06 (2006.01) C07C 57/50 (2006.01) C07C 59/64 (2006.01) C07C 63/49 (2006.01) C07C 63/66 (2006.01) C07C 65/17 (2006.01) C07C 65/21 (2006.01) C07C 65/28 (2006.01) C07C 65/36 (2006.01) C07C 65/38 (2006.01) C07C 65/40 (2006.01) C07C 251/48 (2006.01) C07D 221/08 (2006.01) C07D 265/34 (2006.01) C07D 311/92 (2006.01)

Patent

CA 2233888

Dimer-selective RXR modulator compounds having agonist, partial agonist and/or antagonist activity in the context of an RXR homodimer and/or RXR heterodimers are provided. Also provided are pharmaceutical compositions incorporating such dimer-selective RXR modulator compounds and methods for their therapeutic use.

Composés modulateurs RXR (des récepteurs X de rétinoïde) ayant un effet agoniste, partiellement agoniste et/ou antagoniste dans le contexte d'un homodimère RXR et/ou d'hétérodimères RXR. L'invention porte également sur des compositions pharmaceutiques incorporant de tels composés modulateurs RXR sélectifs pour les dimères et sur des méthodes d'utilisation thérapeutiques de ces compositions.

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