C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 217/02 (2006.01) C07D 217/04 (2006.01) C07D 217/08 (2006.01) C07D 217/12 (2006.01) C07D 217/26 (2006.01)
Patent
CA 2195646
The present invention provides a method of preparing dimeric arylisoquinoline alkaloids by coupling two isoquinoline building blocks, each of which may be the same or different, together with a symmetrical or nonsymmetrical biaryl building block to form homodimers or heterodimers, including the antiviral michellamines. The present invention also provides new, medically useful homodimeric and heterodimeric arylisoquinoline compounds and derivatives thereof.
La présente invention concerne un procédé pour préparer des alcaloïdes du type arylisoquinoléines dimères en couplant deux unités constitutives d'isoquinoléine, qui peuvent être identiques ou différentes, avec une unité constitutive du type biaryle symétrique ou non symétrique, pour former des homodimères ou des hétérodimères, en particulier des michellamines antivirales. La présente invention concerne également de nouveaux composés qui sont des arylisoquinoléines homodimères et hétérodimères et leurs dérivés, et qui sont utiles en médecine.
Boyd Michael R.
Bringmann Gerhard
Gotz Roland
Kelly T. Ross
Department O. F. Health And Human Services The United States Of America Represented By The Secretary
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Trustees Of Boston College (the)
United States Of America Represented By The Secretary Of The Department Of Health And Hum
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