C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 407/12 (2006.01) A61K 31/13 (2006.01) A61K 31/351 (2006.01) A61K 31/7056 (2006.01) A61K 45/06 (2006.01) A61K 47/48 (2006.01) A61P 31/12 (2006.01) A61P 31/16 (2006.01) C07D 309/28 (2006.01)
Patent
CA 2463835
The invention relates to compounds of general formula (I), in which: R is an amino or guanidino group; R2 is acetyl or trifluoroacetyl; n and q are either the same or different and selected from 0, 1 or 2; and X is an optionally substituted phenyl, optionally substituted naphthyl or optionally substituted phenyl-Y-optionally substituted phenyl in which Y is selected from a covalent bond, CH2, CH2CH2, O or SO2, or a pharmaceutically acceptable derivative thereof, with the proviso that when X is phenyl or naphthyl, n and q are both 2 and when X is phenyl-Y-phenyl in which Y is a covalent bond, then n and q are not both 0, methods for their preparation, pharmaceutical formulations containing them or their use in the prevention or treatment of a viral infection.
L'invention concerne des composés représentés par la formule générale (I), y compris leurs dérivés pharmaceutiquement acceptables. Dans ladite formule, R est un groupe amino ou guanidino; R?2¿ est acétyle ou trifluoroacétyle; n et q sont identiques ou différents, valant 0, 1 ou 2; et X est phényle éventuellement substitué, naphtyle éventuellement substitué ou phényle éventuellement substitué -Y- phényle éventuellement substitué, Y appartenant au groupe constitué par: liaison covalente, CH¿2?, CH¿2?CH¿2?, O ou SO¿2?, à condition que, lorsque X est phényle ou naphtyle, n et q valent 2 et que, lorsque X est phényle-Y-phényle, Y étant une liaison covalente, n et q ne valent pas tous les deux 0. L'invention concerne également des procédés relatifs à l'élaboration de ces composés, des formulations pharmaceutiques renfermant lesdits composés, et l'utilisation des composés en question pour la prévention ou le traitement des infections virales
Demaine Derek A.
Jones Haydn T.
Macdonald Simon J. F.
Mason Andrew Mcm.
Shanahan Stephen E.
Biota Scientific Management Pty Ltd
Riches Mckenzie & Herbert Llp
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