Dimeric compounds and their use as anti-viral agents

Details Dimeric compounds and their use as anti-viral agents Dimeric compounds and their use as anti-viral agents

C - Chemistry, Metallurgy

07

D

C07D 407/12 (2006.01) A61K 31/13 (2006.01) A61K 31/351 (2006.01) A61K 31/7056 (2006.01) A61K 38/05 (2006.01) A61K 45/06 (2006.01) A61K 47/48 (2006.01) A61P 31/12 (2006.01) A61P 31/16 (2006.01) C07D 309/28 (2006.01) C07K 5/072 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2463865

The invention relates to compounds of general formula (I); in which R is an amino or guanidino group; R2 is acetyl or trifluoroacetyl; X is CONH, NHCO or O; n is an integer from 2 to 6; and Y is C2-C8 alkyl C3-8 cycloalkyl, C1-C4 alkoxyalkyl, an amino acid or dipeptide, or a pharmaceutically acceptable derivative thereof, methods for their preparation, pharmaceutical formulations containing them or their use in the prevention or treatment of a viral infection.

L'invention concerne des composés représentés par la formule générale (I), y compris leurs dérivés pharmaceutiquement acceptables. Dans ladite formule, R est un groupe amino ou guanidino; R?2¿ est acétyle ou trifluoroacétyle; X est CONH, NHCO ou O; n est un entier compris entre 2 et 6; et Y est alkyle C¿2-8?, cycloalkyle C¿3?-¿8?, alcoxyalkyle C¿1?-¿4?, un acide aminé ou un dipeptide. L'invention concerne également des procédés relatifs à l'élaboration de ces composés, des formulations pharmaceutiques renfermant lesdits composés, et l'utilisation des composés en question pour la prévention ou le traitement des infections virales.

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