Dimeric compounds and their use as anti-viral agents

Details Dimeric compounds and their use as anti-viral agents Dimeric compounds and their use as anti-viral agents

C - Chemistry, Metallurgy

07

D

C07D 407/12 (2006.01) A61K 31/351 (2006.01) A61P 31/12 (2006.01) A61P 31/16 (2006.01) C07D 309/28 (2006.01)

Patent

CA 2462337

The invention relates to compounds of general formula (I); in which R is an amino or guanidino group; R2 is acetyl or trifluoroacetyl; X is CONH, SO2NH, NHCO or NHCONH; m is either 0 or 1; n is an integer from 2 to 6; q is an integer from 0 to 3; and Y is hydrogen or an aromatic substituent, or a pharmaceutically acceptable derivative thereof; methods for their preparation, pharmaceutical formulations containing them or their use in the prevention or treatment of a viral infection.

L invention concerne des composés représentés par la formule (I) ou un dérivé de ceux-ci pharmaceutiquement acceptable. Dans cette formule, R représente un groupe amino ou guanidino; R?2¿ représente acétyle ou trifluoroacétyle; X représente CONH, SO¿2?NH, NHCO ou NHCONH; m est égal à 0 ou 1; n est un nombre entier compris entre 2 et 6; q n est un nombre entier compris entre 0 et 3; et Y représente hydrogène ou un substituant aromatique. L'invention concerne également des procédés de préparation de ces composés, des formulations pharmaceutiques contenant lesdits composés et leur utilisation pour prévenir ou traiter une infection virale.

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