Dimeric compounds and their use as inhibitors of neuraminidase

Details Dimeric compounds and their use as inhibitors of neuraminidase Dimeric compounds and their use as inhibitors of neuraminidase

C - Chemistry, Metallurgy

07

D

C07D 309/28 (2006.01) A61K 31/351 (2006.01) A61K 31/7012 (2006.01) A61K 47/48 (2006.01) A61P 31/16 (2006.01) C12Q 1/70 (2006.01)

Patent

CA 2367755

This invention relates to novel dimeric compounds, methods for their preparation, pharmaceutical formulations thereof, and their use as antiviral agents. The compounds are particularly useful against influenza virus. In particular the invention provides a dimeric compound which comprises two neuraminidase binding molecules attached to a spacer or linking group. Preferably the dimeric molecule comprises two neuraminidase-binding neuraminic acid (sialic acid) or cyclopentyl or cyclohexenyl carboxylic acid derivatives covalently attached to a common spacer group. Pharmaceutical compositions and methods of treatment, prophylaxis and diagnosis are disclosed and claimed.

Nouveaux composés dimères, procédé de préparation desdits composés, compositions pharmaceutiques les contenant et leur utilisation en tant qu'agents antiviraux. Lesdits composés sont particulièrement utiles contre le virus de la grippe. La présente invention concerne en particulier un composé dimère qui contient deux molécules de liaison de la neuraminidase attachées à un groupe écarteur ou de liaison. De préférence, la molécule dimère comporte deux dérivés d'acide neuraminique (acide sialique) ou d'acide cyclopentyle carboxylique ou cyclohexényle carboxylique se liant à la neuramidase attachés de manière covalente à un groupe écarteur commun. Des compositions pharmaceutiques et des méthodes de traitement, de prophylaxie et de diagnostic sont également décrites.

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