Dimeric or multimeric microproteins

Details Dimeric or multimeric microproteins Dimeric or multimeric microproteins

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 38/16 (2006.01) A61K 48/00 (2006.01) C07K 1/00 (2006.01) C07K 14/52 (2006.01) C12N 15/16 (2006.01) C12N 15/62 (2006.01) C07K 14/72 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2600749

Disclosed is a polypeptide comprising at least two microproteins, which preferably comprise an amino acid sequence having a specific binding activity to a target protein. Furthermore, disclosed are polynucleotides encoding such a polypeptide as well as pharmaceutical compositions and kits comprising said polypeptide or polynucleotide. Also disclosed herein are methods of treatments and second medical uses applying the disclosed polypeptide or polynucleotide. Additionally, the disclosure of the present application relates to a method for forming a covalent bond in a microprotein which can be used for producing the disclosed polypeptides.

L'invention concerne un polypeptide comprenant au moins deux microprotéines, lesquelles renferment de préférence une séquence d'acides aminés présentant une activité de liaison spécifique pour une protéine cible. L'invention concerne également des polynucléotides codant pour ce polypeptide ainsi que des compositions pharmaceutiques et des trousses comprenant ce polypeptide ou polynucléotide. L'invention se rapporte en outre à des méthodes de traitement et à des utilisations médicales secondaires faisant appel à ce polypeptide ou polynucléotide. Elle porte enfin sur une méthode destinée à former une liaison covalente dans une microprotéine qui peut être utilisée pour produire les polypeptides susmentionnés.

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