C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 35/04 (2006.01)
Patent
CA 2633962
Certain adducts and dimers of 6-[(substituted)phenyl]triazolopyrimidine compounds or pharmaceutically acceptable salts thereof, and compositions containing said compounds or pharmaceutically acceptable salts thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals, are disclosed. Also disclosed is a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or pharmaceutically acceptable salts thereof. Also disclosed is a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof by promotion of microtubule polymerization which comprises administering to said mammal an effective amount of said compounds and pharmaceutically acceptable salts thereof.
La présente invention concerne certains produits d'addition et dimères de composés de 6-[phényl (substitué)] triazolopyrimidine ou leurs sels pharmaceutiquement acceptables, ainsi que des compositions contenant lesdits composés ou leurs sels pharmaceutiquement acceptables, lesdits composés étant des agents anticancéreux utilisables pour le traitement du cancer chez les mammifères. L'invention concerne également un procédé de traitement ou d'inhibition de la croissance de cellules tumorales cancéreuses et des maladies associées chez un mammifère ainsi qu'un procédé de traitement ou de prévention des tumeurs cancéreuses qui présentent une résistance à plusieurs médicaments (Multiple Drug Resistance; MDR) ou qui sont résistantes en raison d'une MDR chez un mammifère qui en a besoin, ledit procédé comprenant l'administration audit mammifère d'une quantité efficace desdits composés ou de leurs sels pharmaceutiquement acceptables. L'invention concerne également un procédé de traitement ou d'inhibition de la croissance de cellules tumorales cancéreuses et des maladies associées chez un mammifère qui en a besoin en favorisant la polymérisation des microtubules, ledit procédé comprenant l'administration audit mammifère d'une quantité efficace desdits composés ou de leurs sels pharmaceutiquement acceptables.
Beyer Carl
Blum David M.
Wu Yanzhong
Torys Llp
Wyeth
LandOfFree
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