Dimers of unsymmetrical cyanine dyes

Details Dimers of unsymmetrical cyanine dyes Dimers of unsymmetrical cyanine dyes

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07H 21/00 (2006.01) C09B 23/01 (2006.01) C09B 23/02 (2006.01) G01N 33/52 (2006.01)

Patent

CA 2119126

The invention relates to dimers of unsymmetrical cyanine dyes, typically dimers of benzthiazole or benzoxazole derivatives that exhibit enhanced fluorescence on binding with DNA or RNA. The dimers generally have formula (1), where R1 and R2 which may be the same or different, are alkyl groups having 1-6 carbons; X is O. S, or N-R3, where R3 is H or an alkyl group having 1-6 carbons; Z is O, S, or N-R4, where R4 is H or an alkyl group having 1-6 carbons, n and s, which may be the same or different, = 0, 1,or 2;Y is HC=CH; and p, m, q,and r = 0 or 1, such that p + m - 1 and q + r = 1; and where -BRIDGE- has general formula (2), where .alpha.,.beta., .gamma., and .delta., which may be the same or different, are integers greater than 1 and less than 5; 1 and 11, which may be the same or different, = 0 or 1; and A1, A2, and A3, which may be the same or differ- ent, are independently O; S; (CH2)µ where µ = 0 or 1 ; -(NR5)- where R5 is H or an alkyl group having 1-6 carbons; or -(N ? R6R7)- where R6 and R7, which may be the same or different, are independently hydrogen or an alkyl group having 1-6 carbons.

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