Dimethoxy docetaxel acetone solvate et method for the...

C - Chemistry – Metallurgy – 07 – D

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C07D 305/14 (2006.01) A61K 31/335 (2006.01)

Patent

CA 2539309

The invention relates to dimethoxy docetaxel acetone solvate or (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenyl-propionate of 4-acetoxy-2.alpha.-benzoyloxy-5?,20-epoxy-1-hydroxy-7.beta.,10.beta.-dimethoxy-9-oxo-tax-11-ene-13.alpha.-yle and to the preparation thereof by crystallisation from a hydro-acetone solution.

Solvat acétonique du diméthoxy docétaxel ou (2R,3S)-3-tert-butoxycarbonylamino- 2-hydroxy-3-phényl- propionate de 4-acétoxy-2.alpha.-benzoyloxy-5.beta.,20- époxy-1-hydroxy-7.beta.,10.beta.-diméthoxy-9- oxo-tax-11-ène-13.alpha.-yle et sa préparation par cristallisation à partir d'une solution hydro-acétonique.

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