C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/00 (2006.01) A61K 31/70 (2006.01) A61K 31/7084 (2006.01) A61P 9/10 (2006.01) A61P 11/00 (2006.01) A61P 11/10 (2006.01) A61P 27/00 (2006.01)
Patent
CA 2279963
The present invention relates to certain novel dinucleotides and formulations thereof which are highly selective agonists of the P2Y2 and/or P2Y4 purinergic receptor. They are useful in the treatment of chronic obstructive pulmonary diseases such as chronic bronchitis, PCD, cystic fibrosis, as well as prevention of pneumonia due to immobility. Furthermore, because of their general ability to clear retained mucus secretions and stimulate ciliary beat frequency, the compounds of the present invention are also useful in the treatment of sinusitis, otitis media and nasolacrimal duct obstruction. They are also useful for treatment of dry eye disease and retinal detachment.
La présente invention concerne de nouveaux dinucléotides et de nouvelles formulations de ceux-ci, ces dinucléotides constituant des agonistes hypersélectifs du récepteur purinergique P2Y2 et/ou du récepteur purinergique P2Y4. Ces dinucléotides peuvent être utiles au traitement de maladies respiratoires obstructives chroniques, telles que la bronchite chronique, la dyskinésie ciliaire primaire (PCD), ou la mucoviscidose, et peuvent également prévenir la pneumonie due à l'impotence. En outre, de par leur capacité générale à éliminer les sécrétions muqueuses et à stimuler la fréquence des battements ciliaires, les composés de la présente invention sont également utiles au traitement de la sinusite, de l'otite moyenne, et de l'obstruction du canal lacrymo-nasal. Enfin, ils sont utiles au traitement de la kératoconjonctivite sèche et du décollement de la rétine.
Pendergast William
Rideout Janet L.
Siddiqi Suhaib M.
Yerxa Benjamin R.
Gowling Lafleur Henderson Llp
Inspire Pharmaceuticals Inc.
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