Dinucleotides useful for the treatment of lung disease

Details Dinucleotides useful for the treatment of lung disease Dinucleotides useful for the treatment of lung disease

A - Human Necessities

61

K

A61K 31/7084 (2006.01) A61K 9/12 (2006.01) A61K 31/70 (2006.01) A61K 31/7072 (2006.01) A61K 31/7076 (2006.01) A61P 11/00 (2006.01) C07H 21/00 (2006.01) C07H 21/04 (2006.01)

Patent

CA 2223894

A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is disclosed. In a compound of Formula (I): n is from 1 to 6; n is preferably from 2 to 4, and is most preferably 4. X is -OH or -SH, and is preferably -OH. A and B are each independently selected from the group consisting of (a) and (b) wherein R is H or Br. The compounds are useful in the treatment of airway diseases such as cystic fibrosis. Further disclosed are pharmaceutical formulations comprising, in pharmaceutically acceptable carriers (e.g., solid or liquid carriers), a compound of Formula (I) as given above. A method of hydrating mucous secretions in the lungs of a subject in need of such treatment, comprising administering to the lungs of the subject a compound of Formula (I) as given above, is also disclosed. The administering step is preferably carried out by inhalation.

Composés de formule (I), ou sel pharmaceutiquement acceptable dudit composé, dans laquelle n est de 1 à 6, n étant de préférence de 2 à 4, et de préférence encore 4, X est -OH ou -SH et de préférence -OH, A et B sont choisis indépendamment dans le groupe constitué de (a) et (b) dans lesquels R est H ou Br. Ces composés sont utiles dans le traitement de maladies des voies respiratoires, telle que la mucovicidose. Cette invention concerne en outre des formulations pharmaceutiques comprenant, dans des excipients pharmaceutiquement acceptables (par exemple des excipients solides ou liquides), un composé de formule (I) susmentionnée. Est également décrit un procédé pour hydrater les sécrétions muqueuses dans les poumons d'un sujet nécessitant un tel traitement, ce procédé consistant à administrer dans les poumons dudit sujet un composé de formule (I) susmentionnée. La phase d'administration est de préférence réalisée par inhalation.

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