Dioxo-tetrahydroquinoline derivatives

Details Dioxo-tetrahydroquinoline derivatives Dioxo-tetrahydroquinoline derivatives

C - Chemistry, Metallurgy

07

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C07D 401/02 (2006.01) A61K 31/47 (2006.01) C07D 215/22 (2006.01) C07D 215/56 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 405/02 (2006.01) C07D 405/04 (2006.01) C07D 405/06 (2006.01) C07D 409/02 (2006.01) C07D 409/04 (2006.01) C07D 409/06 (2006.01) C07D 409/12 (2006.01) C07D 413/02 (2006.01) C07D 413/04 (2006.01) C07D 417/02 (2006.01)

Patent

CA 2043367

T1077Y ABSTRACT DIOXO-TETRAXYDROQUINOLINE DERIVATIVES A class of 2,4-dioxo-1,2,3,4-tetrahydro- quinoline derivatives, substituted at the 3-position by a range of carbonyl-containing substituents or by a five- or six-membered heteroaromatic moiety, are selective non- competitive antagonists of NMDA receptors and/or are antagonists of AMPA receptors, and are therefore of utility in the treatment of conditions, such as neurodegenerative disorders, convulsions or schizophrenia, which require the administration of an NMDA and/or AMPA antagonist.

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