Dioxopyranoquinoline dicarboxylic acid derivatives

Details Dioxopyranoquinoline dicarboxylic acid derivatives Dioxopyranoquinoline dicarboxylic acid derivatives

C - Chemistry, Metallurgy

07

D

260/275.5

C07D 491/052 (2006.01) C07D 215/48 (2006.01) C07D 311/24 (2006.01) C07D 491/04 (2006.01)

Patent

CA 1112644

DIOXOPYRANOQUINOLINE DICARBOXYLIC ACID DERIVATIVES ABSTRACT There are described compounds of formula I Image I in which an adjacent pair of R5, R6, R7 and R8 form a chain -COCH=CE-O-, and the remainder of R5, R6, R7 and R8, which may be the same or different, each represent hydrogen, hydroxy, alkyl, halogen, alkenyl, alkoxy, or -NR1R2 in which R1 and R2, which are the same or different, are each hydrogen or alkyl, Rg is hydrogen, alkyl, alkenyl or phenyl-alkyl, and E is -COOH, a 5-tetrazolyl group or an (N-tetra-5-yl) carboxamido group, and phrmaceutically acceptable derivatives thereof. There are also described processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing the compounds.

302479

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