Dipeptide apoptosis inhibitors and the use thereof

Details Dipeptide apoptosis inhibitors and the use thereof Dipeptide apoptosis inhibitors and the use thereof

A - Human Necessities

01

N

A01N 1/02 (2006.01) A61K 38/05 (2006.01) C07C 237/22 (2006.01) C07C 271/22 (2006.01) C07C 323/60 (2006.01) C07D 233/54 (2006.01) C07D 277/16 (2006.01) C07K 5/06 (2006.01) C12N 1/04 (2006.01) C12N 5/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2306692

The present invention is directed to novel dipeptides thereof, represented by general Formula (I) where R1-R3 and AA are defined herein. The present invention relates to the discovery that compounds having Formula (I) are potent inhibitors of apoptotic cell death. Therefore, the inhibitors of this invention can retard or block cell death in a variety of clinical conditions in which the loss of cells, tissues or entire organs occurs.

La présente invention concerne de nouveaux dipeptides représentés par la formule générale (I), dans laquelle R1-R3 et AA sont définis. Les composés correspondant à la formule (I) sont de puissants inhibiteurs de la mort cellulaire programmée. Par conséquent, les inhibiteurs décrits dans la présente invention peuvent retarder ou bloquer la mort cellulaire dans diverses conditions cliniques pouvant donner lieu à la perte de cellules, de tissus ou de la totalité des organes.

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