Dipeptide caspase inhibitors and the use thereof

Details Dipeptide caspase inhibitors and the use thereof Dipeptide caspase inhibitors and the use thereof

C - Chemistry, Metallurgy

07

K

C07K 5/06 (2006.01) A61K 38/05 (2006.01)

Patent

CA 2403836

The present Invention is directed to novel dipeptides thereof, represented by general Formula (1): where R1-R2 and AA are defined herein. The present invention relates to the discovery that compounds having Formula (1) are potent inhibitors of caspases and apoptotic cell death. Therefore, the inhibitors of this invention can retard or block cell death in a variety of c11n1ca1 condition in which the loss of cells, tissues or endue organs occurs.

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