Dipeptide crystals, a process for their production, tablets...

Details Dipeptide crystals, a process for their production, tablets... Dipeptide crystals, a process for their production, tablets...

C - Chemistry, Metallurgy

07

K

530/5.06, 99/140

C07K 5/06 (2006.01) A23L 1/236 (2006.01) C07K 1/14 (2006.01) C07K 5/072 (2006.01)

Patent

CA 1341063

A-L-aspartyl-L-phenylalanine methyl ester II type crystals consisting of two types of crystals, II A and II B type, which interconvert from one to the other depending upon the equilibrium moisture content of the crystals, wherein one type of crystal, II A, exhibits X-ray diffraction peaks at angles of diffraction of at least 20.6°, 21.2°, 5.0° and 11.1°, and the other type of crystal., II B, exhibits X-ray diffraction peaks at angles of diffraction of at least 15.2°, 11.1°, 19.6° and 4.5°, as measured by X-ray diffractometry using CuK ~-ray and wherein the equilibrium moisture content of either of the crystals at a temperature at ~4°C and a relative humidity of 78% is not higher than about 3%. The crystals can be used advantageously in tablets or granules containing dipeptide sweeteners and exhibit excellent storage stability.

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