Dipeptide derivatives

Details Dipeptide derivatives Dipeptide derivatives

C - Chemistry, Metallurgy

07

K

530/5.06

C07K 5/062 (2006.01) C07K 5/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1092097

ABSTRACT The invention relates to novel dipeptide derivatives of the general formula Image (I) wherein R is phenyl, substituted-phenyl, lower cycloalkyl or n-(C4-C6)-alkyl group; R1 and R2 each are hydrogen or methyl, with the proviso that R1 and R2 are not simultaneously a hydrogen, or R1 and R2 together are trimethylene; R3 is acyl derived from a carboxylic acid, a sulphonic acid or a sulphinic acid; and the asterisk denotes that the configuration at the carbon atom so-marked is L when R1 is other than hydrogen. The novel dipeptides can be prepared by methods known per se in peptide chemistry and are useful as elastase inhibitors.

280942

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