Dipeptide derivatives

Details Dipeptide derivatives Dipeptide derivatives

C - Chemistry, Metallurgy

07

K

530/5.06

C07K 5/062 (2006.01) C07K 5/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1095027

RAN 4105/29 Canada Abstract The invention is concerned with novel dipeptide derivatives of the general formula Image (I) wherein R is methyl, ethyl, propyl or isopropyl R1 and R2 each are hydrogen or methyl, with the proviso that R1 and R2 are not simultaneously hydrogen, or R1 and R2 together are trimethylene; R3 is acyl derived from a carboxylic acid, a sulphonic acid or a sulphinic acid with the proviso that when the acyl group is derived from an unsubstituted alcanoic acid said acid contains at least 3 carbon atoms; and the asterisk denotes that the configuration at the carbon atom so- -marked is L when R1 is other than hydrogen. The novel dipeptides are prepared by methods known per se in peptide chemistry and are useful as elastase inhibitors.

280966

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