Dipeptide derivatives

Details Dipeptide derivatives Dipeptide derivatives

C - Chemistry, Metallurgy

07

K

C07K 5/065 (2006.01) C07D 213/56 (2006.01) C07D 233/54 (2006.01) C07D 233/64 (2006.01) C07D 263/06 (2006.01) C07D 277/30 (2006.01) C07D 277/46 (2006.01) C07D 295/26 (2006.01) C07D 401/12 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D 409/00 (2006.01) C07D 413/00 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07K 5/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2045008

- 141 - Abstract of the Disclosure. A novel dipeptide derivative of the following formula (I), which compound is capable of inhibiting the enzymatic activity of renin and thereby depressing the renin-angiotensin system and lowering the blood pressure, is provided. Image (I) wherein: R1 is C1-C12 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C10 cycloalkyl, aryl, or heterocyclic radical; R2 is carbamoyl, aryl, 5- or 6-membered heterocyclic radical, C1-C12 alkyl-S-, C1-C12 alkyl-S-CH2-, or C3-C10 cycloalkyl-S-; R3 is aryl or 5- or 6-membered heterocyclic radical; R4 is R4'-SO2 or R4'-CO; R4' is aryl, C1-C12 alkyl, C2-C6 alkenyl, C2-C6 alkynyl; C3-C10 cycloaklyl, or heterocyclic radical; X is CH2, NH, O, or S; and Y is CO or NHSO2, wherein R1, R2, R3 and R4' each may be substituted with one to three substituents selected independently from a group consisting of hydroxy; halogen; - 142 - trifluoromethyl; -CN; heterocyclic radical; C1-C6 alkyl; C3-C10 cycloalkyl; -O-C1-C6 alkyl; C1-C6 alkylenedioxy; -CO-O-C1-C6 alkyl; -NHCO-C1-C6 alkyl; -S-C1-C6 alkyl; -SO-C1-C6 alkyl; -SO2-C1-C6 alkyl; -NHSO2-C1-C6 alkyl; -NR5R6; -O-CO-NR5R6; -CO-NR5R6; -O-C1-C6 alkyl NR5R6; R5 and R6 are independently hydrogen, formyl or C1-C6 alkyl, or R5 and R6, when taken together with the nitrogen to which they are attached, form a cyclic amino group, or an acid addition salt thereof.

Affiliated with

Also associated with

Rating

Dipeptide derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Dipeptide derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dipeptide derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1642543