Dipeptidyl peptidase inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 401/04 (2006.01) A61K 31/506 (2006.01) A61P 3/10 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2559302

Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising Formula (I): STR1 wherein M is N or CR4; Q1 and Q2 are each independently selected from the group consisting of CO, SO, SO2, and C=NR9; and each R1, R2, R3, R4 and R9 are as defined herein.

Des composés, des éléments pharmaceutiques, des kits et des procédés sont utilisés avec DPP-IV et d'autres protéases S9 comprenant un composé de formule I, dans laquelle M désigne N ou CR¿4?; Q?1 ¿et Q?2¿ sont sélectionnés, indépendamment, dans le groupe constitué de CO, SO, SO¿2?, et C=NR¿9?; et chaque R¿1?, R¿2?, R¿3?, R¿4? et R¿9? sont tels que définis dans le descriptif.

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