Dipeptidyl peptidase-iv inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 403/12 (2006.01) A61K 31/4155 (2006.01) A61K 31/4162 (2006.01) A61P 3/10 (2006.01) C07D 207/16 (2006.01) C07D 401/12 (2006.01) C07D 413/10 (2006.01) C07D 413/12 (2006.01) C07D 487/08 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2599419

The present invention relates generally to pyrrolidine and thiazolidine DPP-IV inhibitor compounds. The present invention also provides synthetic methods for preparation of such compounds, methods of inhibiting DPP-IV using such compounds and pharmaceutical formulations containing them for treatment of DPP- IV mediated diseases, in particular, Type-2 diabetes.

La présente invention concerne de manière générale des composés de pyrrolidine et de thiazolidine inhibiteurs de la DPP IV. L'invention concerne également des procédés synthétiques de préparation de ces composés, des procédés d'inhibition de la DPP IV au moyen de ces composés et des formulations pharmaceutiques contenant lesdits composés pour traiter des maladies à médiation par la DPP IV, notamment le diabète de type 2.

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