Diphenyl-dihydro-imidazopyridinones

Details Diphenyl-dihydro-imidazopyridinones Diphenyl-dihydro-imidazopyridinones

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2684008

This invention is related to a compound of formula (1) and the pharmaceutically acceptable salts thereof, wherein X, R1, R2, Y1 and Y2 are as described herein. These compounds inhibit the interaction of MDM2 protein with a p- 53-like peptide and therefore exhibit antiproliferative activity.

L'invention concerne un composé représenté par la formule (I) et les sels pharmaceutiquement acceptables de ce composé, X, R1, R2, Y1 et Y2 ayant la signification donnée dans le descriptif. Les composés selon l'invention inhibent l'interaction des protéines MDM2 avec un peptide de type p-53 et présentent par conséquent une activité antiproliférative.

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