Diphenyl ether compounds useful in therapy

Details Diphenyl ether compounds useful in therapy Diphenyl ether compounds useful in therapy

C - Chemistry, Metallurgy

07

C

C07C 323/20 (2006.01) A61K 31/137 (2006.01) A61K 31/18 (2006.01) A61K 31/41 (2006.01) A61P 15/10 (2006.01) C07C 237/28 (2006.01) C07C 311/37 (2006.01) C07D 231/38 (2006.01) C07D 249/06 (2006.01) C07D 249/08 (2006.01)

Patent

CA 2404439

A compound of general formula (I), or pharmaceutically acceptable salts, solvates or polymorphs thereof; wherein R3 is independ ently CF3, OCF3, C1- C4alkylthio or C1-C4alkoxy; n is 1, 2 or 3; and the other variables are as defined in the claims. These compounds inhibit monoamine re-uptake and in particular exhibit activity as selective serotonin re-uptake inhibitors. They are useful in disorders such as depression, attention deficit hyperactivity disorder, obsessive-compulsive disorder, post-traumatic stress disorder, substance abuse disorders and sexual dysfunction including premature ejaculation.

Composés représentés par la formule (I) ou leurs sels acceptables sur le plan pharmaceutique, leurs solvates ou polymorphes; dans laquelle chaque R?3¿ représente indépendamment CF¿3?, OCF¿3?, alkylthio C¿1?-C¿4? ou alcoxy C¿1?-C¿4?; n est 1, 2 ou 3; les autres variables étant telles qu'elles sont définies dans les revendications. Ces composés inhibent la recapture des monoamines et, en particulier, exercent une activité en tant qu'inhibiteurs sélectifs de la recapture de la sérotonine. Ils sont utiles pour des troubles tels que la dépression, le déficit de l'attention, l'hyperactivité pathologique, les troubles compulsifs obsessionnels, les troubles post-traumatiques, la toxicomanie et le dysfonctionnement sexuel, y compris l'éjaculation précoce.

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