Diphenyl-methane derivative and pharmaceutical use

Details Diphenyl-methane derivative and pharmaceutical use Diphenyl-methane derivative and pharmaceutical use

C - Chemistry, Metallurgy

07

C

167/179, 260/295

C07C 251/40 (2006.01) C07C 59/64 (2006.01) C07C 251/60 (2006.01) C07C 255/41 (2006.01) C07C 255/62 (2006.01) C07C 255/64 (2006.01) C07D 207/46 (2006.01) C07D 257/04 (2006.01) C07D 339/08 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1296338

ABSTRACT OF THE DISCLOSURE A new diphenyl-methane derivative is useful to inhibit agglomeration of blood and is defined by the formula including a diphenylethylene derivative and a benzophenone oxime ether derivative. ( X X ) Image in which R1 and R2 each are hydrogen hydroxyl or a lower alkoxy U is =CXY or =N-O-W, x is hydrogen cyano or -COR6, R6 being hydroxyl or an amino Y is -R10-COOR3 R3 being hydrogen or a lower alkoxy R10 being an alkylene having 1 to 3 carbon atoms straight or branched -CO-NR4R5, R4 and R5 each being hydrogen a lower alkyl or a lower arylalkyl CH2-NHS02-C6H5 or -C(R8)=NR7, R7 being a lower alkoxy or an aryl R8 is -VR9 V being oxygen sulfur or nitrogen R9 being an alkyl or an aryl, W is -CH2-CO-CH2-COOR13, R13 being hydrogen or a lower alkyl -CH2-C(=NOR14)-CH2-COOR15, R15 being hydrogen or a lower alkyl, R16 being a lower alkyl -CH(CN)-(CH2)q-COOR16, R16 being hydrogen or a lower alkyl, q being an integer of 1 to 3, or -(CH2)p-Z, Z being -SH, -SCN or a monovalent group derived from a five- or six-membered ring which may be substituted by a ring having one or more sulfur atoms in the ring, p being 1 or 2.

532108

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