Diphenylalkyl-tetrahydropyridines, process for their...

C - Chemistry – Metallurgy – 07 – D

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C07D 211/70 (2006.01) A61K 31/445 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2274946

The invention relates to compounds of the formula Image in which: Y is -CH- or -N-; R1 is a halogen or a CF3,(C1-C4)alkyl or(C1-C4)alkoxy group; R2 and R3 are each hydrogen or a (C1-C3)alkyl; n is 0 or 1; and Ph1 and Ph2 are each independently an unsubstituted, monosubstituted or polysubstituted phenyl group; to a process for their preparation and to the pharmaceutical compositions containing them. These compounds have neurotrophic and neuroprotective activity.

L'invention concerne des composés de formule (I) dans laquelle: Y représente -CH- ou -N-; R1 représente un halogène, un groupe CF3, (C1-C4)alkyle ou (C1-C4)alcoxyle; R2 et R3 représentent chacun l'hydrogène ou un (C1-C3)alkyle; n représente 0 ou 1; Ph1 et Ph2 représentent chacun, indépendamment un groupe phényle non substitué, mono- ou polysubstitué, ainsi qu'un procédé pour leur préparation et les compositions pharmaceutiques les contenant. Ces composés ont une activité neurotrophique et neuroprotectrice.

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